![]() Surmodics (Nasdaq:SRDX) announced today that it received formal feedback from the FDA related to its SurVeil drug-coated balloon (DCB). SRDX shares slipped -1.4% to $18.48 apiece in mid-afternoon trading.įiled Under: Catheters, Mergers & Acquisitions Tagged With: NorMedix, SurModics Inc. Groshong Central Venous Catheters, Groshong NXT ClearVue Peripherally Inserted. Ancora Heart, Egnite partner on AccuCinch trial enrollment. The company raised its revenue outlook from between $60 and $64 million to between $62 million to $66 million. Available in five lengths from 65 to 200 cm and compatible with 0.014, 0.018, and 0.035 guidewires, the Sublime microcatheters feature Surmodics’ best-in-class Pristyne hydrophilic coating for. “NorMedix has been focused on addressing challenging healthcare problems with pioneering design and development capabilities and is a strong fit with SurModics’ culture, capabilities and commitment to providing innovative healthcare solutions to help patients.”Įden Prairie, Minn.-based SurModics, which saw its share price take a hit after it lowered its guidance due to the Creagh buyout, lowered its as-reported earnings outlook from 38¢ to 43¢ per share to between 30¢ and 35¢ per share (adjusted EPS are still pegged at 66¢ to 75¢). Our ReVene Venous Thrombectomy Catheter, which received FDA 510(k) clearance in fiscal 2021, is a mechanical thrombectomy catheter for use in venous vascular beds that is specifically designed to remove large, mixed-morphology blood clots commonly found with VTE. “We are pleased to be joining the SurModics team, recognizing the strategic fit of our design and development expertise with SurModics’ innovative coating technologies,”added NorMedix president & CEO Gregg Sutton, who’s slated to join SurModics as R&D vice president. Looking at the SRDX split history from start to finish, an original position size of 1000 shares would have turned into 2000 today. “We remain focused on being a strategic partner to industry-leading medical device companies by offering early access to innovative whole-product solutions.” “With NorMedix we will have a differentiated catheter-technology platform and additional design and development expertise that will enhance the value we offer our medical device customers,” president & CEO Gary Maharaj said in prepared remarks. Title: Sublime Radial Access 014 Case Report (Dr. Federa a restricts this deice to sae or on the order o a phsician or proper icensed practitioner. Plymouth, Minn.-based NorMedix makes thin-walled catheters, according to SurModics, which inked a $32 million deal for Creagh Medical late last year. The ReVene Thrombectomy Catheter has the potential to significantly expand the use and accessibility of venous mechanical thrombectomy by allowing physicians to intervene early and complete the procedure in a single session, said Stephen Black, principal investigator and leading enroller of the VETEX feasibility study and Consultant. The IVUS catheter was removed and a Sublime 2.0 mm x 220 mm balloon was inserted, advanced to the pedal loop and inflated for two minutes (Figure 2). SurModics (NSDQ: SRDX) said today that it acquired NorMedix for $14 million, including $7 million in up-front cash and another $7 million in revenue milestones.
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Using phosphate starvation to induce the secretory expression, the protocol could be generally used for the efficient production of Fabs.Įxtracellular production Fab PhoA STII Secretion.Ĭopyright © 2019 The Authors exclusive licensee Bio-protocol LLC. Using anti-VEGF Fab as an example, here we provide a protocol based on the alkaline phosphatase (phoA) promoter and the heat-stable enterotoxin II (STII) leader sequence. In addition, the extracellular expression allows for the direct harvesting of proteins from the culture supernatant, sparing the procedures of cell lysis and reducing contamination of host cell protein or DNA. The extracellular expression is of particularly interest since it releases the product into the medium, while periplasmic expression yield is limited to the periplasm space. The secretory expression of proteins in periplasm or extracellular medium are promising strategies to prevent the formation of inclusion bodies to improve the efficiency to produce Fabs from E. coli, which has been the bottleneck for exogenous protein expressions using this system. Protein Expression and Affinity Purification from E Coli (1 liter). However, the disulfide-bonds containing exogenous protein, including Fab, tend to form insoluble inclusion bodies in E. SnapGene is a program which allows researchers to plan, visualize, and document their. ![]() Therefore, Fab can be cost-effectively produced using an Escherichia coli (E. G T G C A G ( N ) 14 N N C A C G T C ( N ) 14Įfficient cleavage requires at least two copies of the BsgI recognition sequence.In comparison with full-length IgGs, antigen binding fragments (Fabs) are smaller in size and do not require the complexed post-translational modification. Sticky ends from different BstXI sites may not be compatible. PciI is inhibited by nonionic detergents.Ĭ C A N N N N N N T G G G G T N N N N N N A C C ![]() Sticky ends from different AflIII sites may not be compatible. Sticky ends from different AhdI sites may not be compatible.Įfficient cleavage requires at least two copies of the PluTI recognition sequence.Įfficient cleavage requires at least two copies of the NarI recognition sequence. ![]() Get a rare look inside Lee Broom’s New York penthouse during NYCxDesignįrank Lloyd Wright’s renovated Westhope lists for $7. Here are some other common responsibilities of a lighthouse keeper: Performing maintenance tasks Cleaning windows and lenses Winding clocks Replenishing fuel Replacing bulbs or trim wicks Checking automated systems Using fog signals Taking weather readings Making logbook notations Assisting in. Maison Brummell Majorelle has a birds-eye view of Marrakech’s favourite botanic park Pamela Rosenkranz plants a hot pink tree atop New York’s High Line Medieval country manor asks for £2.85m in KentĬopenhagen’s Nikolaj Kunsthal has a reverential new cafe and storeĪlain Prost’s Ferrari F40 is up for auction with no reserve This red cabin on Canada’s Lake Ontario is a cosy autumn retreatįancy being a lighthouse keeper in Canada? The government is hiring The major snag? You must be residing in Canada, a Canadian citizen or a permanent resident living abroad to be considered. Salary expectations range from $45,241 and $60,707, with an application deadline of 31 December 2023. Applicants need experience operating and repairing mechanical and electrical equipment, such as generators and power tools, and a valid Restricted Operators certificate or higher.ĭay-to-day duties range from reporting weather conditions and relaying radio messages to grounds maintenance of the station and its cistern, refuelling diesel tanks, painting buildings, and testing fire pumps and equipment. While it might sound idyllic, it’s a pretty tough job. ![]() From 1918 to 1949, raised a family here and there are wonderful stories and photographs from the Gresham. Applicants will depart for Victoria, Port Hardy, Tofino, Bella Bella or Prince Rupert – suggesting several roles available to service remote locations such as Trial Island, Triple Island, Quatsino, Cape Beale, and Boat Bluff. The longest-serving keeper, John Young Gresham, did the job for more than 30 years. The role is for an assistant lighthouse keeper working along British Columbia’s stunning coast and is offered through the Department of Fisheries and Oceans Canada and the Canadian Coast Guard. If ‘me time’ and remote locations are your thing, then this posting from the Canadian government for a lighthouse keeper could be right up your street. Manually adding new entries is very simple. ![]() If one entry is updated, RoboForm will automatically offer to update any identical entries elsewhere in your vault. RoboForm also allows you to “clone” entries, so you can easily save the same login in multiple folders (including shared folders). You can either leave all entries in the main vault, or you can organize everything into folders and subfolders - of which you can create as many as you like. In RoboForm’s vault, you can store logins and passwords, website bookmarks, secure notes, identities, and contacts. RoboForm’s password vault is accessible via its desktop app, web app, browser extension, and mobile apps. I would however like to see RoboForm add more comprehensive data breach monitoring like Dashlane or encrypted storage like Keeper. Overall, RoboForm has all the features you need to keep your passwords safe, its detailed form fields save lots of time if you regularly fill forms online, and it makes it super easy to change compromised or weak passwords. RoboForm also offers most features I expect in a quality password manager, including: ![]() This all means that even if RoboForm’s servers are breached or in case of a government subpoena, your data is completely safe. And the end-to-end encryption used for password sharing means that only the sender and the intended recipient(s) have the “key” to decrypt the data. Local encryption means all your data is encrypted and decrypted locally on your device using your master password (which RoboForm has no record of) before being sent to RoboForm’s servers. It keeps user data private with local and end-to-end 256-bit AES encryption, which is the same super-high level of encryption used by many banks and militaries around the world. This also means its servers have to be protected with the strongest encryption algorithms possible. RoboForm stores user passwords on its servers, which allows for multi-device syncing, password sharing, and remote vault access. Plus, all RoboForm plans are backed by a 30-day money-back guarantee, so there’s no risk in trying it out. That said, RoboForm is cheaper than many premium competitors (and even cheaper with this 42% off discount), with affordable premium plans for both individuals and families. And while RoboForm does offer data breach monitoring, it’s a far more basic version than that of other top password managers. ![]() However, RoboForm lacks extra features that other competitors offer, such as Dashlane’s VPN, or 1Password’s unique Travel Mode (hidden vaults). In my tests, it saved me a huge amount of time by allowing me to navigate and fill complex web forms with ease. RoboForm’s form-filling is also unique with the amount of detail it allows. For example, third-party 2FA apps like Google Authenticator easily sync up to RoboForm, and I had no trouble sharing passwords and notes between different users and accounts. ![]() RoboForm’s additional features are really well made, too. It uses strong encryption methods (256-bit AES) to ensure your login credentials and confidential data are secure, has a very user-friendly interface, and is very affordable. RoboForm is one of the best password managers in 2023. ![]() Once the members heard the initial idea for "Carry On Wayward Son," they knew the songwriting gold that they had on hand and went straight into the recording studio without even pausing to rehearse the track. Luckily, guitarist Kerry Livgren was overflowing creatively with ideas and he still had one song that he hadn’t shared with the band. Taking a short breather to record what would become their fourth album, 1976's Leftoverture, frontman Steve Walsh ran into writer’s block. Like many groups in the time period, Kansas toured and recorded relentlessly, supporting three albums that sold modestly despite their growing live following. The now-familiar a capella intro for "Carry On Wayward Son" was the sonic hook that would help Kansas score their first major hit, a feat that was a long time coming for the band. We're guessing record sales from this song have paid for that ticket many times over by now. ![]() "I Can't Drive 55," as Hagar has explained many times, was inspired by a real-life incident that found him pulled over for doing 62 late at night on an empty highway in upstate New York. This new level of fame also paved the way for him to join Van Halen in 1985. We're not saying Hagar was directly responsible for the late-'80s national law changes that allowed states to once again set speed limits higher than 55, but it certainly couldn't have hurt. ![]() Nearly a decade of constant touring and increasing record sales – remember "Your Love Is Driving Me Crazy?" – had already established Hagar as a rock star prior to the release of his 1984 VOA album.īut the Red Rocker really hit a nerve with the message of the record's first single, which – aided by a truly entertaining video – quickly made him a household name and bona-fide arena headliner. Who better to get our Top 100 Classic Rock Songs list off to a fast start than Sammy Hagar and his anti-speed limit anthem, "I Can't Drive 55?" Mom cleaned rooms, did all the laundry, waited on customers, unclogged toilets anything that needed to be done she would do. They lived at the motel for over 30 years and worked very hard to make it into the successful business it became. They added on to the motel so that it had triple the number of rooms it had when they bought it and triple the amount of work. In 1979, Mom and Dad moved into town where they took over the operation of the Star Lodge Motel which they then purchased in 1980. Mom and Dad were also 4-H leaders for many years. What adventures we had and we met so many amazing and wonderful people. We drove in our crew cab truck with the big overhead storage rack, hauling our horses around the state and to many other states. In the summer of 1964, Dad’s job with Great Northern Railroad transferred him to Glasgow so they moved their family to the home out on Skylark Road where they had a huge garden and raised a multitude of animals.ĭuring the summers while us kids were growing up, the whole family traveled to O-Mok-Sees. Mom and Dad welcomed all six of their kids while living in Havre: Marie, James, FayeAnn, Paula (who died at birth), Ronald, and Richard. They made their home in Havre, Montana where Dad worked outside the home and Mom opted to stay home and take care of the kids and the household. Mom married Dad, William “Bill” Fewer on September 1, 1956. ![]() The Dodson School Superintendent always told her that she wasn’t valedictorian because she was so smart it was just that the rest of the class was so dumb! She attended school in Dodson, Montana, graduating in 1957 at the head of her class. ![]() A private graveside service will be held at a later date.Īlthough her birth certificate said April 29, Mom always claimed that she was born on April 27, 1939, to Lloyd and Mary (Lemp) Tribby. Paw Paw, Michigan obituaries further detail where the woman in question grew up, attended schools and worked.Shirley A Fewer, 84, passed away during the early morning hours of Thursday, April 27, 2023, at Frances Mahon Deaconess Hospital in Glasgow, Montana. For example, Paw Paw, Michigan obituaries might reveal to you that the subject was born in 1957, and that she had four siblings. ![]() Paw Paw obituaries include personal information on the character of the deceased and the accomplishments to his/her name. However, Paw Paw Michigan obituaries also contain information you cannot get elsewhere, including Michigan cemetery records, which usually only have transcriptions and years. Results are instant and can confirm the information you are searching for. While looking up these records on microfilm would be a chore, with online Paw Paw obituaries, all you need is a name, state of death, and year of death. Thousands of people die in Paw Paw each year, and most of these people are mentioned in local Michigan obituaries. Yes, you now have the opportunity to search for Paw Paw obituaries. A fairly recent phenomenon is the archiving of these Paw Paw obituaries, first through microfilm, and then through online databases. In fact, Paw Paw, MI newspaper articles originally published Michigan obituaries. Paw Paw obituaries, unlike death records, contain detailed information about the person's life - not just the name and date of death. Searching for Paw Paw Obituaries and Death RecordsĪre you looking for Paw Paw obituaries and death records? While this is very useful in researching a family name, you are actually limited in what you can find when you search only for basic information. ![]() Learn to be patientĭon’t run around like a mad photographer chasing an insect that won’t sit still. Metering Mode: Pattern Macro Photography Tips 3. This macro was taken with a Canon 400D SLR camera, a Canon EF 100mm f/2.8 Macro lens and a Canon Macro Twin Light MT-24EX flash. If I hadn’t turned this lens setting off, it would have kept swimming or refocusing, making it near impossible to capture a sharp image of the hoverfly. As the hoverfly was constantly moving, I found turning off the lens AF (automatic focus) function made the job so much easier. Learn to use manual focus when shooting insects. Metering Mode: Pattern Macro Photography Tips 2. Photograph of a hoverfly in flight was taken with a Canon 400D SLR entry level camera, a Canon EF 100mm f/2.8 Macro lens and a Canon Macro Twin Light MT-24EX flash.Įxposure (shutter speed): 0.005 sec (1/200) Hand holding your camera for macro photography makes it easier to nail the shot. This is perhaps high on my list of macro photography tips. Like many macro photographers, I find a tripod really restrictive when photographing insects. It also allowed me to hand hold the camera without the use of a tripod. ![]() Having the ability to keep the shutter speed at a fast 1/200th of a second allowed me to capture the moving insect sharply. Using a Canon Macro Twin Light MT-24EX flash allowed me to keep the aperture on a high f/11 without sacrificing shutter speed (exposure). ![]() The photo shown below was shot in a shady part of the garden. However we recommend keeping it in mind for later on. I understand it isn’t always possible for beginner photographers to purchase external flash. Using a flash will allow you to shoot at a reasonable speed, yet enable you to keep the aperture on a high f/11 for sufficient depth of field. Use a ring flash or twin light flash when shooting macro You’ll also notice they were photographed with an entry level camera, demonstrating that anyone with a DSLR can shoot awesome macro photographs. Many of the images below have been taken with a Canon EF 100mm f/2.8 Macro lens, the settings can be reproduced with any real macro lens. Each photograph also includes an explanation of the camera equipment that was used and camera settings. Shown below is a set of ten amazing macro images with macro photography tips for the relevant image. The still shows a player with his arms outstretched to the sides. Next, the artist is seen from above placing the Galaxy Z Fold4 on the table in Flex mode with the video still playing. Certain applications may not support multitasking. Below is a group chat cheering on the team. On top, the artist is watching a soccer game on YouTube. Next, the device’s screen is being used horizontally. Availability of feature may vary by country or region. Drag and drop feature requires the latest Microsoft Office app, minimum version sixteen point zero point one five three three zero point two zero two zero four or above. The Excel sheet data shows numbers from the Fibonacci Sequence. Next, he drags an image of the Vitruvian Man from an Excel sheet to a PowerPoint slide with his finger. S Pen Fold Edition sold separately and is only compatible with Z Fold4 and Z Fold3. He draws a diagram resembling the cake on the plate on the Notes app with the S Pen Fold Edition. Next, an overhead view of the screen shows the Gallery app and the Samsung Notes app are open together on one screen. Next, an overhead view of the screen reveals that he is referencing a photo of a square cake on a round plate. He sits and opens the device to the Main Screen. The artist grabs a Graygreen Galaxy Z Fold4 from the table behind him. Next, it can be seen that the canvas was blank. Samsung logo.Ī man dressed in European Renaissance period clothing points a paint brush at a canvas. The resulting photo is vivid with sharp details and well framed. A friend takes photos of Gadget Match’s Michael Josh as he poses for the camera. When viewed from the rear, the Cover Screen is displaying a live preview from the Rear Cameras like a mirror for the subject to see themselves. He taps the Cover Screen Preview icon in the Camera app, and a popup indicates that the Cover screen preview is on. Michael Josh from Gadget Match is in a city setting to demonstrate the camera features. Quote from MKBHD: “The hidden selfie camera is actually very impressive.” A shot of the Main Screen shows that the camera is not visible when viewed directly from the front. The display is rotated to an angle to reveal the hidden camera located on the Main Screen. Next, a close up shot of the Under Display Camera. Next, the camera pans over the devices to showcase the three different colors. Now, three Galaxy Z Fold4 devices are in front of Unbox Therapy, representing three available colors: Graygreen, Phantom Black and Beige. Supersaf demonstrates how to use the Taskbar by tapping on app icons to quickly switch between apps. Then, the shot zooms in to the new Taskbar at the bottom of the display, including an App Pair icon. On an unfolded Main Screen, the Setting menu is in Multi View. Quote from Supersaf: “It is still mind-blowing that we’ve got a foldable device that has water resistance.” Multitasking. Next, Supersaf excitedly sprays water from a garden hose. Next, as MKBHD speaks, a close up view of the Cover Screen and hinge. One is in Graygreen and one is in Phantom Black. Quote from Supersaf: “This is a little bit more durable for the back as well as the cover display.” Supersaf holds a folded Galaxy Z Fold4 device in each hand with the rear cover facing up. Quote from MKBHD: “Firm and confidence-inspiring.” Next, a close up of the top edge of the device as it folds closed. ![]() MKBHD twirls the device in his hand to provide a close up of various angles of the device, including a close shot of the rear cameras. Quote from Unbox Therapy: “A phone and a tablet that’s in your pocket at all times.” Supersaf holds a folded Galaxy Z Fold4 in Graygreen in his hand. ![]() ![]() On the table in front of Unbox Therapy are two black Galaxy smartphone boxes. A view of the Main Screen, folded to stand vertically. Availability of model and colors may vary by country and carrier. A license was obtained for a fee after content was posted on YouTube. No payment was made to create the review. ![]() Disclaimer: Tech reviewers share their thoughts on the Galaxy Z Fold4. Expert Supersaf is seen in his studio speaking directly to the camera. If not for the coronavirus, Zoom probably wouldn't have taken such a deep delve into the security and privacy issue for some time.īut, what does that mean for Jitsi Meet? Is it truly more secure than Zoom? Yuan, chief executive of Zoom Video Communications, openly admits that the sudden stratospheric rise of Zoom caught the team napping. Privacy and security issues abound, along with various commonly encountered Zoom errors, and the management and development teams are left scrambling to fix a raft of issues.Įric S. ![]() Unfortunately for Zoom, it wasn't ready for the level of scrutiny that would follow. Jitsi allows you to live-stream your video conference to an external streaming service, such as YouTube, to increase your number of viewers without negatively impacting on the video conferencing quality. You can work around this limitation using the integrated live-streaming option. However, for best results, the development team suggests limiting that number to a maximum of 35 participants otherwise, "the experience will suffer." Jitsi Meet supports up to 75 participants at the current time. For the majority of users, the regular Jitsi video web chat and smartphone apps are perfect. However, for the more technically minded, you can download and install the Jitsi Meet software to a private server, drastically increasing your privacy. Anyone can click the link, create a video call, and begin chatting. The version included in the link is the web deployment of the Jitsi Meet software. ![]() Jitsi Meet is a secure video conferencing app you can use to chat with people from a web browser, Android, or iOS app. ![]() (SOUNDBITE OF AHMAD JAMAL'S "THEME FROM MASH") For the first set, Jamal played his current single, the theme from "MASH," for 45 minutes. One of the first jazz concerts I ever saw, circa 1973, remains one of the oddest. WHITEHEAD: In the late 1960s, Ahmad Jamal's reputation again began to wane as he made albums with choirs, strings and electric piano. (SOUNDBITE OF AHMAD JAMAL'S "ALL OF YOU") The dramatic turnabouts and sudden big gestures, playful quotations from other tunes and a powerful sense of swing. But some recently unearthed mid-'60s recordings from Seattle confirm his old virtues were intact. But as a devout Muslim, he didn't sell alcohol, and the place soon folded. WHITEHEAD: With newfound success, Ahmad Jamal opened his own Chicago club. A 1958 live album recorded in Chicago's Pershing Hotel lounge yielded his hit version of the 1936 Latin tune "Poinciana." It was Jamal's bread-and-butter song ever after and a lifesaver for the Argo label and its parent, Chess Records. He swapped out Ray Crawford's guitar for drums in a more conventional lineup. Ahmad Jamal's next phase won him wider acclaim. WHITEHEAD: "Slaughter On 10th Avenue," 1955. (SOUNDBITE OF AHMAD JAMAL TRIO'S "SLAUGHTER ON 10TH AVENUE") He heard his trios as miniature orchestras. That stuff could make Ahmad Jamal's music sound a little fussy. ![]() Miles also picked up on the pianist's way of tweaking a tune's form with little interludes and extensions. Miles Davis testified to Jamal's influence on his own understatement and use of space and silence. Nowadays, we praise Jamal's economy and dramatic shifts in density and volume. Early on, some folks dismissed that trio for making fussy, glorified cocktail music. The pianist's reputation had its ups and downs over the years. KEVIN WHITEHEAD, BYLINE: Ahmad Jamal's first recording, "The Surrey With The Fringe On Top," Chicago, 1951. (SOUNDBITE OF AHMAD JAMAL TRIO'S "THE SURREY WITH THE FRINGE ON TOP") Here's our jazz critic, Kevin Whitehead, with a look back on Jamal's career. He was born and raised in Pittsburgh, broke through with his small-group music in Chicago in the 1950s and recorded scores of records through 2016, a 65-year recording career. Pianist Ahmad Jamal died on April 16 at age 92. The Owls scored on drives of four and three plays on their first two possessions of the second half, the latter capped by Smith's long scoring run.This is FRESH AIR. Tulane came back with two quick touchdowns in the second quarter, and the teams traded touchdowns after that as Tulane led 24-21 at the half. The Owls drove 69 yards in eight plays, capped by Wall's 25-yard run, and Armstrong finished a 10-play, 52-yard drive with a 4-yard run on the first play of the second quarter. Rice jumped to a 14-3 lead early in the second quarter. 9, 2004, when the Owls beat SMU 44-10 in Houston. Rice's Chad Price broke up a fourth-down pass with 1:22 to play, and Taylor intercepted a Scott Elliott pass with five seconds to go for the final stop. Five plays later, Armstrong threw the scoring pass to Wood. The Green Wave led 31-28 before Smith's score and pulled within 35-34 on a 22-yard field goal by Jacob Hartgroves with 9:06 left in the game.īut Rice's Carl Taylor recovered a fumble by Matt Forte at the Tulane 42-yard line with 6:14 to play. Tulane (2-7, 1-5), which played in its ninth different stadium, extended its losing streak to six games after starting the season 2-1. The Owls (1-8, 1-5 Conference USA) gave themselves a cushion on a 29-yard touchdown pass from Joel Armstrong to tight end Joe Don Wood with 4:45 left in the game. Wall scored from 25 and 75 yards before a 1-yard plunge, and Smith's 58-yard run provided the last of eight lead changes, putting Rice ahead 35-31 midway through the third quarter. Wall and backfield mate Quinton Smith each had 20 carries, with Smith pitching in another 143 yards and a touchdown. HOUSTON (AP) - John Wall rushed for 156 yards and three touchdowns as Rice rolled up 392 yards on the ground, ending the nation's longest losing streak at 14 games with a 42-34 victory against Tulane on Saturday. |